Am J Med Sci. 2013 Mar;345(3):195-9.
doi: 10.1097/MAJ.0b013e3182548c28.
Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol.
Source
Internal Medicine E Department (SH, AH, TH) and Lipid Research Laboratory (SH, EM, TH), Technion Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel; Clinical Biochemistry Laboratory (MK), Technion Faculty of Medicine, Rambam Medical Center, Haifa, Israel; and Medical Department (RT, RC), Merck, Sharp and Dohme, Hod Hasharon, Israel.Abstract
ABSTRACT:: Oxidative stress has been implicated in the pathogenesis of
cardiovascular disorders, including atherosclerosis. In pharmacological doses,
niacin (vitamin B3) was proven to reduce total cholesterol, triglyceride,
very-low-density lipoprotein, and low-density lipoprotein levels, and to
increase high-density lipoprotein (HDL) levels. The aim of this study was to
evaluate the effect of niacin treatment in patients with low levels of HDL
cholesterol
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