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Showing posts with label Type II diabetes. Show all posts
Showing posts with label Type II diabetes. Show all posts

Wednesday, October 3, 2012

Book Review: Don’t Die Early - Rocky Angelucci (Naughton reviewed)

Sep062012

Book Review: Don’t Die Early

Posted by Tom Naughton

Lying on the gurney in the emergency room, I shielded my eyes from the glaring overhead lights and tried to remember exactly when my heart went wacko. I remember being anxious and out of sorts all evening. Looking back, I realized that during dinner my chest felt fluttery and strange inside, and I recall snapping at my wife, Laura, over nothing as I left the kitchen to go upstairs.

By the time I reached the top of the stairs, I knew something was very wrong— I could barely breathe and when I placed my fingers to the side of my neck, my pulse felt very unusual. Not the rhythmic beating I would have expected, but more like an indistinct, squishy fluttering. Walking into our spare bedroom, I retrieved the pulse meter from the shelf next to the treadmill. I slipped the meter on my finger and looked at the readout. The effort seemed exhausting. Sitting on the edge of the bed, I called for Laura. When she arrived a moment later, I handed her the pulse meter.

The display read 195 beats per minute and I knew my life had just changed forever. The old carefree way of taking care of my body that had worked fine in my youth and young adulthood wasn’t working anymore. I now had to become a conscious advocate of my own health.

That’s the opening from Don’t Die Early, an educational and very well-written book by Rocky Angelucci – who did nearly die early. Finding yourself lying on a gurney should certainly put a scare into you, but unfortunately many people respond to that scare by following their well-meaning doctor’s orders … you know, cut back on the eggs and saturated fats, eat your hearthealthywholegrains, etc.

Rocky didn’t go that route, partly (and I’m delighted to say this) because of Fat Head. As he explained in an email some months ago:

I have been a fan of yours since discovering a snippet of Fat Head on YouTube the evening I returned home from the hospital following a life-changing episode of atrial fibrillation. I was only 45 years old at the time, but had just been rudely awakened by the realization that the carefree lifestyle of my youth had become increasingly harmful. Fat Head’s discussion of insulin resistance and fat storage resonated very well with my pre-med college days studying life sciences and my experiences with the Zone diet and the hormonal implications of foods. Fat Head also catalyzed my growing displeasure at a procedure-driven medical system and gave substance to my vague feeling that politics, not science, has infiltrated medical care.

Because my underlying cardiac problem ultimately turned out to be an alarming plaque burden, my research quickly lead me to Dr. William Davis’ Track Your Plaque forum, where I have been a very active member for the past two years. I became so impressed with Dr. Davis that he has been my cardiologist for the past year. His warmth and prevention-minded attitude makes the journey from Dallas to Wisconsin entirely worthwhile. Thanks to my radical lifestyle changes, most of them flying in the face of conventional wisdom, I’m fortunate to be one of the TYP members who has shown dramatic plaque reversal, recently showing a 24% six-month decrease immediately following a horrific 83% increase the year before.

If I had heart disease, there’s no one in the world I’d rather have treating me than Dr. Davis. Rocky’s in good hands.

His email continued:
Emboldened by a background as a technical writer in the fields of software, nanotechnology, and medical devices, I’ve spent the past year writing a book on preventive health that captures what I’ve learned and applied to my own condition.

I read the book before it was published and again last week, and it’s excellent. When I consider recommending a book (publishers send me books I don’t recommend, by the way), I ask myself two questions: 1) Is the information useful to people who want to lose weight or become healthier? 2) Does it pass my “Aunt Martha” test … that is, could your Aunt Martha read it and understand it?
The answer to both questions in this case is an enthusiastic yes. Rocky has a gift for taking the science of nutrition and health and explaining it clearly, and it’s obvious from the many topics he covers and how well he covers them that he jumped into that science head-first. I learned more from this book than I thought I would, which is always a pleasure.

As the title indicates, Don’t Die Early isn’t about weight loss. It’s about how to live to a ripe old age and remain healthy along the way. Weight loss is covered in a section about dietary fallacies, but Rocky’s goals for the reader are the same goals he set for himself: 1) understand the true causes of heart disease, diabetes and inflammation; 2) learn how to reliably measure and track the instigators or markers of those diseases, such as LDL particle size and A1C; and 3) take specific actions to reverse disease or prevent it from developing in the first place.

That’s what Rocky did, and was rewarded with excellent results:
In the first six months after embracing a preventive lifestyle, I accomplished the following:
  • Lowered my body fat percentage from 20% to 11%
  • Lowered my inflammatory markers by as much as 75% (you’ll learn about inflammation later)
  • Reduced my triglycerides by more than 90% (this happened in the first 30 days)
  • Improved every measurable aspect of my cholesterol
  • Improved my fasting glucose by 25%
  • Improved my muscle tone and stamina
  • Lowered my blood pressure from an average of 145/90 to an average of 115/70
  • Reduced my resting heart rate by more than 13 points
As impressive as these results might appear, I’m not revealing them so that you’ll invite me to your next party. They are to show you what is very attainable for anyone who makes the proper lifestyle changes.

The book is divided into two parts. Part One, titled The Major Players, provides in-depth explanations of heart disease, diabetes and inflammation. The message Rocky pounds home in these chapters is that it’s important not only to understand what these diseases actually are and what causes them, but to know specifically what to measure so you can tell if you’re developing them. Sadly (but not surprisingly), the tests your doctor orders often add up to too little, too late:

Imagine having the following conversation with your child’s teacher:

You: How is my daughter doing in school this semester? Is she learning the required material?

Teacher: Based upon her age, and what we infer her socioeconomic status to be, as well as her assertions that she does homework on a regular basis, we believe she has a very high likelihood of having mastered this semester’s materials acceptably.

You: Excuse me? What does this mean? Have you tested her on the material?

Teacher: No, we compared her socioeconomic status, apparent nutritional health, and her testimony that she does her homework regularly to a statistical model we have and there’s a strong correlation between your daughter’s parameters and students who mastered the coursework. Oh, and we measured the callouses on her writing fingers and they indicate that she’s likely doing quite a bit of writing, which our statistical model shows increases by 22% her chances of having mastered the material. Overall, we feel very confident that she has mastered this semester’s material.

You: I don’t understand why you’re comparing her to a statistical model instead of testing her. Do you ever plan on testing her?

Teacher: Only if she shows clear signs of having failed to master the material would we test her. As long as her parameters correlate acceptably to the statistical models of a successful population, we will assume that she is mastering the material.

Does this sound like a school you would like your child to attend? Does estimating your child’s performance by comparing indirect parameters to a statistical model sound like an ideal way to gauge her mastery of the subject matter? It certainly doesn’t to me.

Yet this is how our medical culture typically measures the risk of coronary artery disease during routine preventive exams.

That’s why Rocky didn’t know he was developing plaque in his arteries. He quotes Dr. William Davis, who says that the traditional methods of identifying people at risk for heart disease miss 90 percent of the people who eventually have a heart attack. If you want to know if you’re developing plaque, you should (surprise!) measure plaque.

The standard test for measuring diabetes often misses those who are developing it as well:
Many of the clinical guidelines in use today encourage a physician to use fasting glucose as the sole indicator of one’s diabetic health. Seeing a fasting glucose level within the laboratory “normal” range, both patient and physician are satisfied that the patient is at low risk of Type 2 diabetes.

Now that you know more about how diabetes progresses, you can see that gauging the risk of Type 2 diabetes solely on fasting glucose is terribly ineffective. An abnormal fasting glucose is typically the last commonly used indicator to show the presence of diabetes. In fact, by the time your fasting glucose is no longer in the normal range, you are already diabetic.

Throughout these chapters, Rocky explains which health markers you should be actually measuring and which specific tests you can request from your doctor or order online and perform at home.
Fat Head fans will be familiar with much of material on heart disease and diabetes, including how much of the standard advice from so-called experts is wrong. But even though I’ve read quite a bit on those topics, I kept coming across information in Don’t Die Early that was either new to me or struck me as particularly well-explained. Here are a couple of sample bits:

Perhaps the biggest problem with insulin being a growth hormone is that not all of the tissues in the body become desensitized to increasing levels of insulin at the same rate. As a person becomes more and more insulin-resistant, cells that are much less affected continue to respond to the ever-increasing levels of insulin, growing and multiplying more rapidly as insulin levels increase. What cells exhibit this behavior? The endothelial cells that form the lining of your arteries, for one. As these arterial cells multiply more rapidly, the lining of an insulin-resistant person’s arteries thicken and grow inward, hastening coronary artery disease. This is one of the reasons why so many diabetics die from heart disease.

A typical cell membrane is composed of a lipid bilayer, which is just what it sounds like: two layers of fatty acid molecules, sandwiched together to give cell membranes their much-needed strength. This bilayer also forms an effective barrier to foreign substances, through the use of embedded receptors that are designed to transfer only specific things into and out of the cell. The impermeable lipid layers and their receptors serve as gatekeepers to help ensure the health of a cell by transferring only what the cell needs, in the right amounts, into the cell and removing unwanted substances from within the cell. Virtually anything that the cell consumes or produces is transported this way, ensuring that only the proper substances ever reach the interior of the cell.

As with most structures of the body, the cell’s lipid bilayer needs to be constantly maintained, which the body does by constantly replenishing the crucial fatty acids that comprise the cell membranes. What happens if a person eats a trivial amount of healthy omega-3 fatty acids and an abundance of unhealthy omega-6 fatty acid? Simple, the body does its best with what you give it and will use the omega-6 fatty acids instead.

What this means is that in addition to their role in promoting inflammatory chemical messengers, omega-6 fatty acids become incorporated into virtually every cell in your body.

Part two of the book, Lifestyle Changes, includes chapters on dietary truths and fallacies, setting goals, and taking action. Again, the chapter on diet covers ground that’s largely familiar for Fat Heads (Gary Taubes and Dr. William Davis are quoted several times), but it’s well written and worth the read.

In the final two chapters, Rocky urges the reader to do enough testing to establish several baseline measurements (blood sugar, fasting insulin, vitamin D concentration, LDL particle size, etc.), set specific and attainable goals for improving those markers, then work to meet them. If you’ve ever wondered what your fasting insulin level or vitamin D concentration should be (ideally, anyway) this chapter will tell you. Rocky also gives advice on how to improve your odds of meeting each goal. For example, to achieve optimum triglyceride levels:

In summary, the best approach to reducing one’s triglycerides is
  • Eliminate grains, replacing them with vegetables, nuts, and berries.
  • Minimize carbohydrates (especially fructose), eating them in sufficient moderation so as to never cause unfavorable glucose levels.
  • Consider supplementing your diet with omega-3 fatty acids from fish oil.
  • Speak to your physician about supplementing with niacin to help optimize your triglycerides.
  • All of the above steps will very effectively control your fasting triglycerides. To really take it to the next level, buy a Cardio-Chek triglyceride meter to measure your body’s response to different types of meals to identify exactly how sensitive your body is to specific types and quantities of fats. If you perform a small series of these carefully controlled tests, you’ll have infinitely more clarity on how to optimize your diet for the best possible postprandial triglyceride production (this will be especially valuable in determining whether saturated fat is good for you and at what level).
Near the very end of the book, there’s a section I’m sure many of you will relate to … the sub-chapter heading is Prepare To Be An Outcast. Here’s chunk of that section:

You may find yourself biting your tongue every time you see a friend, colleague, or loved one wolf down a low-fat, grain-based meal, laden with vegetable oil, as they complain about having acid reflux or autoimmune disorders.

You may see friends and loved ones struggle with weight problems while they eat low-fat foods that constantly elevate their blood glucose level, ensuring that they live life as the “walking starving,” trying unsuccessfully to lose weight.

Even your more health-conscious friends may not appreciate your one-upping them on matters of health and nutrition. Responding to their enthusiasm for fish oil with “Yes, but do you track your daily intake of omega-3 and omega-6 fatty acids and have you ever checked your Omega-3 Index?” will make you sound like a know-it-all.

It’s painful to realize that some people just don’t want to hear that there’s a better future available to them if they just abandon the current thinking on what’s healthy and what’s not. Many refuse to believe that they could ever get bad advice from a physician or from a “trusted” source like the USDA, the American Dietetic Association, or the American Diabetes Association. In such cases, you may just need to silently watch them continue on their path.

Sadly, that’s true. But for people who are open to trying a new path to health, Don’t Die Early is an excellent guidebook.
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Read the full article here.

Monday, September 3, 2012

Statins linked with development of cataracts - O'Riordan

Statins linked with development of cataracts
Waterloo, ON - Statin users are more than 50% likelier to develop age-related cataracts, according to the results of a new study. And type 2 diabetics who use statins are at even greater risk of cataracts, report investigators.
 
"The bioplausibility of these results lies in the fact that the crystalline lens membrane requires high cholesterol for proper epithelial cell development and lens transparency," write Dr Carolyn Machan (University of Waterloo, ON) and colleagues in the August 2012 issue of Optometry and Vision Science. "Increased cataract formation has been seen in both animals and humans with hereditary cholesterol deficiency, and the risk exists that statins can inhibit cholesterol biosynthesis in the human lens."
 
Asked to comment on the paper for heartwire, Dr Richard Karas (Tufts University School of Medicine, Boston, MA), called the findings "an interesting observation [that] isn't alarmist." There is, he says, a "suggestion" here that statins may increase the risk of cataracts, but this visual problem eventually afflicts everyone of a certain age anyhow, he says, adding that further study of this association will be required.
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Read complete article here.

Monday, August 13, 2012

Statins linked with development of cataracts - theheart.org

Statins linked with development of cataracts

August 13, 2012 Michael O'Riordan
Waterloo, ON - Statin users are more than 50% likelier to develop age-related cataracts, according to the results of a new study [1]. And type 2 diabetics who use statins are at even greater risk of cataracts, report investigators.

"The bioplausibility of these results lies in the fact that the crystalline lens membrane requires high cholesterol for proper epithelial cell development and lens transparency," write Dr Carolyn Machan (University of Waterloo, ON) and colleagues in the August 2012 issue of Optometry and Vision Science. "Increased cataract formation has been seen in both animals and humans with hereditary cholesterol deficiency, and the risk exists that statins can inhibit cholesterol biosynthesis in the human lens."

Asked to comment on the paper for heartwire, Dr Richard Karas (Tufts University School of Medicine, Boston, MA), called the findings "an interesting observation [that] isn't alarmist." There is, he says, a "suggestion" here that statins may increase the risk of cataracts, but this visual problem eventually afflicts everyone of a certain age anyhow, he says, adding that further study of this association will be required.

Waterloo Eye Study includes almost 6500 patients
The analysis included 6397 patients with and without diabetes. As the researchers note, diabetes is a risk factor for the development of cataracts, leading the group to analyze the prevalence of cataracts among patients with diabetes taking statins (n=452) and the prevalence among those taking statins but without diabetes (n=5884). The mean age of patients with diabetes was 14 years older than those without diabetes and included a slightly higher proportion of female subjects. The prevalence of statin use in patients 38 years of age and older was 56% for those with type 2 diabetes and 16% for those without diabetes.

In the study, known as the Waterloo Eye Study, diabetes was associated with an 86% higher risk of developing cataracts (odds ratio [OR] 1.86; 95% CI 1.34-2.59) across the lifespan after researchers controlled for multiple variables, including age, female sex, smoking, and blood pressure. A diagnosis of diabetes was also associated with an increased risk of different subtypes of cataracts: an 84% greater risk of nuclear sclerosis, a 38% higher risk of cortical cataract, and a 52% rise in posterior subcapsular cataract

Statin use was also associated with a significantly increased risk of developing age-related cataracts (OR 1.57; 95% CI 1.15-2.13) and some subtypes, including a 48% higher risk of nuclear sclerosis and a 48% rise in posterior subcapsular cataract but no increased risk of cortical cataract.

In an analysis of cataract prevalence among patients with and without diabetes taking statins, Machan and colleagues found that the prevalence of cataract increased at a faster rate in patients with diabetes who used statins. "Similar prevalence levels were seen in patients with diabetes who did not use statins and in patients without diabetes who did use statins," according to the researchers. "The prevalence of cataract increased at the slowest rate in patients without diabetes who did not use statins."
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Read the full article here.

Tuesday, April 17, 2012

Evidence based medicine

Following quoted from Chris Kresser.
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I was talking with a colleague the other day (let’s call her M). M related a story one of her patients told her. This patient is a nurse at Kaiser. The nurse was telling M about a meeting she recently attended with the rest of the clinical staff at Kaiser. The purpose of the meeting was to inform all of the doctors and nurses about new clinical guidelines for preventing heart disease.

And what were these clinicians told? To encourage their patients to eat fewer refined carbs, less vegetable oil and less sugar? To engage in a stress management program? To get a moderate amount of physical activity?

Hardly. They were told, in a nutshell, to give everyone statins. The idea communicated to them was that statins are “like vitamins” (a direct quote), and should be distributed in a similar manner.
This got me thinking about the concept of “evidence-based medicine”. I’m all for it, by the way. Evidence-based medicine, that is. The problem is that it doesn’t really exist in the conventional medical model.

Actually, I take that back. It does exist. But to be more accurate we’d have to call it “20-or-30-year-old-evidence-based medicine”. That’s a more representative term for the kind of medicine being practiced today.

The story above is a perfect case in point. The evidence is clear that statins don’t work. (If you don’t believe that, watch this presentation.) Furthermore, the evidence is also clear that the low-fat, high carbohydrate, vegetable oil-fueled diet promoted for decades by the American Heart Association (AHA) has not only failed to prevent heart disease, it has promoted it.

Anyone who actually reads the scientific literature with an open mind and a critical eye could reach these conclusions. The studies aren’t top secret. They’re not kept in an underground fortress. They’re readily available online or at your local medical library.

Yet in spite of the overwhelming evidence against statins and the low-fat AHA diet, this is still the standard of care for heart disease in the medical profession.

I wish I could say this is an isolated case. But you see the same thing in just about every disease or health condition. The standard of care for hypothyroidism is a complete joke. (More on this after I pass my licensing exam, I promise!) Type II diabetes can, for the vast majority of people, be managed and prevented by a low-carb diet. GERD is treated with PPIs and acid stopping drugs, in spite of the evidence that it is actually caused by low stomach acid in most cases.

Maybe the best example, though, is the 2010 dietary guidelines recently published by the USDA. Tom Naughton over at Fat Head published a post on this recently, so I’ll just crib from that:
I started reading the USDA’s 2010 Dietary Guidelines this week. For those of you who hoped the federal government would finally wise up and dump the high-carb/low-fat nonsense … come on, you didn’t really expect that, did you?

Did you honestly believe the government would put together a panel of so-called experts who would announce that the government has been wrong for the past 40 years? That the food pyramid was a disaster? That billions of taxpayer dollars are subsidizing the same foods that are making us fat and diabetic?

Of course not. The new guidelines are, if anything, a perfect example of something I’ve said in previous posts (which I believe I may have borrowed from Milton Friedman): when a government program produces disastrous results, those results are offered as proof that we need to do the same thing again … only bigger!

That’s mostly what the new guidelines are: the same old $#@%, only bigger. Bigger reductions in saturated fat, bigger reductions in salt, bigger reductions in cholesterol, and of course (this is a government committee, after all) lots of “calls to action” … otherwise known as BIG federal programs to convince us poor fools in the public to finally start heeding their advice.
Everywhere you look, you see medicine that isn’t evidence-based – or medicine that’s based on evidence that’s ten, twenty and even fifty years old.

The truth is we don’t have evidence-based medicine. We have profit-based medicine. And as long as the insurance and pharmaceutical companies are running the show, that’s what we’ll continue to have.

Did you know Big Pharma is the second-most profitable industry in the world, behind only the oil industry? Did you know that these companies fund 2/3 of all medical research? Do you really think honest-to-goodness evidence-based medicine is even a possibility in this environment?

Luckily we’ve got the Internet, and some conscientious and intelligent researchers and medical professionals that are willing to look beneath the veil and share what they find with the rest of us.

These days that’s really our only hope as people trying to live healthy lives: to be our own advocates, to seek out information that comes from people without a vested financial interest in selling you something, to maintain a “healthy skepticism” (if I may use the term) about any claims made, whether they come from the conventional or alternative world.

Because let’s face it, evidence-based medicine is a myth.
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Read the full article here.

Tuesday, February 28, 2012

FDA Expands Advice on Statin Risks




If you’re one of the millions of Americans who take statins to prevent heart disease, the Food and Drug Administration (FDA) has important new safety information on these cholesterol-lowering medications.

FDA is advising consumers and health care professionals that:

  • Routine monitoring of liver enzymes in the blood, once considered standard procedure for statin users, is no longer needed. Such monitoring has not been found to be effective in predicting or preventing the rare occurrences of serious liver injury associated with statin use.
  • Cognitive (brain-related) impairment, such as memory loss, forgetfulness and confusion, has been reported by some statin users.
  • People being treated with statins may have an increased risk of raised blood sugar levels and the development of Type 2 diabetes.
  • Some medications interact with lovastatin (brand names include Mevacor) and can increase the risk of muscle damage.
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Read the rest of the FDA article here.

Sunday, February 27, 2011

No-Bologna Facts from Tom Naughton

No-Bologna Facts

  • There’s never been a single study that proves saturated fat causes heart disease.
  • As heart-disease rates were skyrocketing in the mid-1900s, consumption of animal fat was going down, not up. Consumption of vegetable oils, however, was going up dramatically.
  • Half of all heart-attack victims have normal or low cholesterol. Autopsies performed on heart-attack victims routinely reveal plaque-filled arteries in people whose cholesterol was low (as low as 115 in one case).
  • Asian Indians - half of whom are vegetarians - have one of the highest rates of heart disease in the entire world. Yup, that fatty meat will kill you, all right.
  • When Morgan Spurlock tells you that a McDonald’s salad supplies almost a day’s allowance of fat, he’s basing that statement on the FDA’s low-fat/high-carbohydrate dietary guidelines, which in turn are based on … absolutely nothing. There’s no science behind those guidelines; they were simply made up by a congressional committee.
  • Kids who were diagnosed as suffering from ADD have been successfully treated by re-introducing natural saturated fats into their diets. Your brain is made largely of fat.
  • Many epileptics have reduced or eliminated seizures by adopting a diet low in sugar and starch and high in saturated animal fats.
  • Despite everything you’ve heard about saturated fat being linked to cancer, that link is statistically weak. However, there is a strong link between sugar and cancer. In Europe, doctors tell patients, “Sugar feeds cancer.”
  • Being fat is not, in and of itself, bad for your health. The behaviors that can make you fat - eating excess sugar and starch, not getting any exercise - can also ruin your health, and that’s why being fat is associated with bad health. But it’s entirely possible to be fat and healthy. It’s also possible to be thin while developing Type II diabetes and heart disease.
  • Saturated fat and cholesterol help produce testosterone. When men limit their saturated fat, their testosterone level drops. So, regardless of what a famous vegan chef believes, saturated fat does not impair sexual performance.