Niacin significantly reduces oxidative stress

Am J Med Sci. 2013 Mar;345(3):195-9. doi: 10.1097/MAJ.0b013e3182548c28.

Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol.

Hamoud S, Kaplan M, Meilin E, Hassan A, Torgovicky R, Cohen R, Hayek T.

Source

Internal Medicine E Department (SH, AH, TH) and Lipid Research Laboratory (SH, EM, TH), Technion Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel; Clinical Biochemistry Laboratory (MK), Technion Faculty of Medicine, Rambam Medical Center, Haifa, Israel; and Medical Department (RT, RC), Merck, Sharp and Dohme, Hod Hasharon, Israel.

Abstract

ABSTRACT:: Oxidative stress has been implicated in the pathogenesis of cardiovascular disorders, including atherosclerosis. In pharmacological doses, niacin (vitamin B3) was proven to reduce total cholesterol, triglyceride, very-low-density lipoprotein, and low-density lipoprotein levels, and to increase high-density lipoprotein (HDL) levels. The aim of this study was to evaluate the effect of niacin treatment in patients with low levels of HDL cholesterol
.
.
.
==================================================================
Read complete article here.