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Showing posts with label Vitamin D. Show all posts
Showing posts with label Vitamin D. Show all posts

Friday, February 14, 2014

Cholesterol is absolutely vital for our existence - Attia

the essential nature of cholesterol

 

 
 
 
“Cholesterol is absolutely vital for our existence.       
  Peter Attia, MD
 
Let’s note right off the bat, there’s no such thing as ‘good and bad’ cholesterol. As shown below, cholesterol is a single natural substance – the grandmother steroid – featuring a four-ring structure of carbon atoms.

All steroid hormones (such as Vitamin D) are made from cholesterol, but, as we shall learn, cholesterol is much more than a hormone.

 
Cholesterol is made in a complex 27-step process from the 2-carbon substance called acetyl-CoA. The 4-ring structure is the chemical signature of a steroid. On the bottom left, there’s a hydrocarbon tail (HO), where cholesterol esterifies (or attaches) to other molecules and a hydroxyl group- top right.
 
Classified as a fat-soluble lipid, cholesterol is not a fat, it has no calories, and it’s not a source of energy. Cholesterol is a sterol – a high molecular weight alcohol. Animals, plants, and microorganisms require different sterols.
 
Cholesterol is the animal sterol – found in every cell in animal bodies. It is true that, as a minor component, cholesterol can be found in plant membranes, but the sterols  sitosterol and stigmasterol predominate in plants.
 
According to UK lipid biochemist Michael Gurr:   “Only cholesterol will allow animal cells to function as required. Without cholesterol, our bodies would not function properly and we would die.”
 
Cholesterol waterproofs our trillions of membranes, making it possible for our cells to regulate their internal environments – policing and maintaining “cellular security.” Cholesterol also plays a key role in intra and inter-cellular communications and signaling.
 
Cholesterol ensures that the cell’s lipid bi-layer (two layers of fat in phospholipid form) is neither too rigid nor too flexible. If that’s not enough, cholesterol is the goddess-like precursor to all adrenal, steroid and sex hormones such as estrogen and testosterone. Without cholesterol, we could not stand, move, think, respond to stress – or reproduce!
 
Cholesterol is also a major component of bile, an emulsifier required for dietary fats to be broken down and utilized. As a constituent of bile – on its singular route out of the body – cholesterol coats our slowly transiting feces. Only the liver can order cholesterol out of the body – and much of it is recycled.  Sorry Cheerios!
The liver is the main site of cholesterol synthesis, but every cell can make cholesterol (except nervous tissue).  Our bodies contain up to 100 grams of cholesterol – 90 percent in cell membranes and the rest dissolved in adipose and other tissues. The highest concentration (25 percent) is in the nerve cell connections and in the myelin that protects brain and nervous tissue.
 
In particular, infants need a large amount of cholesterol for proper brain development – and very large amounts of cholesterol are supplied in human milk – not in formula. Cholesterol is needed to properly form the part of the brain that allows the eyes to develop normally. In young and old alike, cholesterol is a primary raw material for many healing processes.

As an example, when an injury occurs on the Teflon-like, slick endothelial layer in an artery – say from high blood sugar – the body’s first responders are cholesterol, blood platelets, specialized white blood cells, and other materials that patch up the injury – similar to a scab forming over a break in the skin.

In the Optimal Diet, eggs are a “free food.”
 
“Cholesterol is absolutely essential for life,” writes Peter Attia, MD, President and co-Founder of the Nutrition Science Initiative:

“The animal body must have cholesterol to function properly and  to manufacture vital hormones and chemicals.”

And, for people whose bodies may not properly synthesize cholesterol, cholesterol in food may be a conditionally essential nutrient.

As you may note, the medical profession has utterly failed to properly describe the essential nature of cholesterol. Future editions of Diet Heart News will continue to expound on the importance of cholesterol and saturated fat in the American diet.
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Read the complete article here.

Monday, January 13, 2014

Does Wheat Cause Coronary Heart Disease?

Does Wheat Cause Coronary Heart Disease?

Introduction

Coronary heart disease (CHD) is the leading cause of deaths worldwide - killing 7 millions people every year. In the following text, we will see that wheat consumption is probably a risk factor for CHD.

Conventional Wisdom on Wheat

Most health organizations currently view wheat as a safe food except for people having celiac disease - affecting up to 1% of the population - and people having non-celiac gluten sensitivity. Also whole wheat - as part of whole-grains - is considered to be one of the healthiest food. In fact a diet rich in whole-grains is considered to be protective against CHD.

Why? Because observational studies consistently find that whole-grain consumption is associated with a decreased risk of CHD. Do these results contradict wheat consumption causing CHD?

Are Whole-Grains Protective Against CHD?

According to this study:
Whole-grain intake consistently has been associated with improved cardiovascular disease outcomes, but also with healthy lifestyles, in large observational studies. Intervention studies that assess the effects of whole-grains on biomarkers for CHD have mixed results.
Indeed many studies show that whole-grain consumption is associated with a decreased risk of CHD. But these studies are observational and can only show correlation but not causation.

In fact there is an health-conscious population bias in these studies: for example people consuming the most whole-grains also exercise more and smoke less:
Whole-grain intake and lifestyles
Data from Majken K Jensen et al., Intakes of whole grains, bran, and germ and the risk of coronary heart disease in men, 2004

Of course researchers adjust the data with these risk factors. But it is very difficult, maybe impossible, to adjust for all risk factors. For example the two previously cited studies did not adjust for important risk factors like socioeconomic status or social support.

A classic example of an occurrence of this bias can be found in hormone replacement therapy (HRT): observational studies had found that HRT was decreasing the risk of heart disease risk while a controlled study finally found that HRT was indeed slightly increasing the risk of heart disease.

A proof that this health-conscious bias could explain the seemingly protective effect of whole-grains can be found in randomized controlled studies: many of them fail to find any beneficial effect of whole-grains compared to refined grains.

So according to these randomized controlled studies whole-grains are neutral toward CHD risks. How then can we say that wheat causes CHD?

Are All Grains Created Equal?

Many randomized controlled studies compared wheat with other grains. These trials are usually quite short. So instead of looking at the number of heart attacks, short-term studies focus on risk predictors of CHD like weight gain or markers of inflammations. Apolipoprotein B (ApoB) level is another risk factor. It represents the number of LDL particles - often called “bad cholesterol”. It is now considered to be a better predictor than LDL-C - the amount of cholesterol contained in LDL particles. The lower the level of ApoB the lower is the risk of CHD.

Here are some results of these studies:
  • a study concluded that a bread diet may promote fat synthesis/accumulation compared with a rice diet
  • wheat increased BMI compared to flaxseed in a 12 months study
  • wheat increased ApoB level by 5.4% compared to flaxseed in a 3 weeks study
  • wheat increased ApoB level by 7.5% compared to flaxseed in a 3 months study
  • wheat increased ApoB level by 0.05 g/L compared to flaxseed in a 12 months study
  • oat decreased ApoB level by 13.7% while wheat had no significant effect in a 21 days study
  • wheat increased the number of LDL particles by 14% while oat decreased them by 5% in a 12 weeks study
  • ApoA to ApoB ratio (a risk predictor similar in efficiency to ApoB alone - here the higher the better) was increased by 4.7% for oat bran and 3.9% for rice bran compared to wheat bran in a 4 weeks study
These studies show that some grains like oat improve the risk factors of CHD compared to wheat. In addition, these studies often show an absolute improvement of the CHD risk profile in groups eating oat and an absolute deterioration in groups eating wheat. Although we cannot say for sure, it would suggest that oat is protective against CHD - which is confirmed by other studies - while wheat increase the risk of CHD.

That could help explaining why people eating more whole-grains are healthier in observational studies since it looks like that they eat more grains like rice and oat and less typically wheat-made food like white bread, pasta and doughnuts:
Whole-grain intake and different grain intakeData from Andersson A. et al., Intakes of whole grains, bran, and germ and the risk of coronary heart disease in men, 2007

Now let’s have a look at studies linking wheat and CHD.

Observational Studies on Wheat

Some observational studies linked wheat and waist circumference gains - waist circumference being a strong predictor of CHD:
  • a study showed a correlation between consumption of white bread and waist circumference gains
  • a study concluded that: ”reducing white bread, but not whole-grain bread consumption, within a Mediterranean-style food pattern setting is associated with lower gains in weight and abdominal fat
  • a Chinese study found that ”vegetable-rich food pattern was associated with higher risk of obesity” but as noted by obesity researcher Stephan Guyenet the association between obesity is in fact stronger with wheat flour than with vegetables
A more pertinent result is found in the data of a large observational study in China. Researchers analysed these data and found a 0.67 correlation between wheat flour intake and CHD. They also found a 0.58 correlation between wheat intake and BMI.
CHD mortality and wheat intake
From Denise Minger
But this is just a single unadjusted correlation and does not prove much. However blogger Denise Minger thoroughly analysed the data of this study and found that the association held strongly after multivariate analysis with any other variable available like latitude, BMI, smoking habits, fish consumption, etc.

Since it is an observational study it cannot prove anything but it is yet another evidence suggesting that wheat consumption causes CHD. Let’s now have a look at randomized controlled trials.

Randomized Controlled Trials on Wheat

In addition to the previous randomized controlled trials comparing wheat with other grains there are two additional studies suggesting that wheat consumption causes CHD.

The first one is a study involving rabbits. While studies involving animals are not always relevant to humans - especially studies with herbivore animals like rabbit - the results of this study are quite interesting.

The researchers fed rabbits an atherogenesis diet (i.e. promoting formation of fatty masses in arterial walls) with a supplement of cottonseed oil, hydrogenated cottonseed oil, wheat germ or sucrose. And as they concludes:
Severity of atherosclerosis after 5 months was greatest on the wheat germ-supplemented diet, whereas there were no differences among the other three groups.
The second study is the Diet And Reinfarction Trial (DART). In this 2-year randomized controlled trial, people who already had recovered from an heart attack were split into groups receiving various advices. The main result of this study was that the group advised to eat fatty fish had a reduction in mortality from CHD.

One other advice - the fibre advice - was:
to eat at least six slices of wholemeal bread per day, or an equivalent amount of cereal fibre from a mixture of wholemeal bread, high-fibre breakfast cereals and wheat bran
Seeing this advice we can guess that most of cereal fibres intake by this group was from wheat although we cannot be sure.

This advice resulted on a 22% death increase:
Total mortality in the fibre advice groupFrom Stephan Guyenet
However this result bordered on statistical significance: the 95% confidence interval being 0.99–1.65.
For people not familiar with statistics, a result is usually defined as statistically significant when there is less than 5% chance that the result is due to luck alone. Here there is a 95% probability that the relative risk is between 0.99 (1% decreased chance of dying) and 1.67 (67% increased chance of dying).

Since the probability that the fibre advice resulted in a protective or neutral effect was a little too high, this result has been quite overlooked. Had the study last a little longer, it would have raised way more suspicion toward whole-grains.

In fact, researchers found this effect to be statistically significant in a follow-up study. After adjusting for pre-existing conditions and medication use, we can see in the table 4 of this study an hazard ratio of 1.35 (95% CI 1.02, 1.80) for the 2-year period of the randomized controlled trial.

These results are quite telling: according to these researchers, a 2 year randomized controlled trial showed that advising people recovering from an heart attack to eat at least six slices of wholemeal bread per day resulted in a statistically significant 35% percent chance increase of CHD compared to people not receiving this advice.

Wheat, Vitamin D Deficiency And Heart Disease

Many studies found that vitamin D deficiency is associated with CHD.
However vitamin D deficiency does not seem to cause heart disease. For example several studies found that vitamin D supplementation did not prevent heart disease.
As this study concludes:
A lower vitamin D status was possibly associated with higher risk of cardiovascular disease. As a whole, trials showed no statistically significant effect of vitamin D supplementation on cardiometabolic outcomes.
Wheat consumption causing CHD could help explaining these results. A study found that wheat consumption depletes vitamin D reserves. That could explain why vitamin D deficiency is associated with heart disease and why it does not seem to cause it: both vitamin D deficiency and heart disease could be consequences of wheat consumption.

Of course this is not the only explanation. For example the DART study shows that fish consumption prevents CHD and fish is a food rich in vitamin D.

Not the Perfect Culprit

To be clear, if it seems likely that wheat consumption is a risk factor of CHD it is not the only one nor the primary one. There are many other factors like smoking, hypertension, lack of exercice or stress. Even among dietary factors wheat is probably not the main one. For example the DART study shows that the protective effect of fish intake is stronger than the adverse effect of wheat.

In addition, deleterious wheat effects might not affect everybody. One study showed that the ApoB level variation following wheat and oat bran intake was different depending on the genotype of the individuals. In another study whole-wheat intake worsened the lipid profile only in people having a specific genotype compared to refined wheat.

How the wheat is cooked may have a role too. Studies show that sourdough bread improve mineral bioavailability (such as magnesium, iron, and zinc) compared to yeast bread or uncooked whole-wheat. Also content in proteins with potential adverse consequences like gluten or wheat germ agglutinin differs depending of the food type.

Conclusion

There are strong evidences that wheat consumption is a risk factor for CHD. People at risk of CHD should avoid wheat as should those trying to lose weight. In all cases, stopping wheat consumption for a month for example to see how one feel without wheat is always a good idea since there is currently no available method to diagnose non-celiac wheat sensitivities and that even for celiac disease the average delay in diagnostic is 11 years in the US.

More studies looking at the links between wheat and CHD are urgently needed since CHD is the leading cause of deaths while wheat is the second most widely consumed food and whole-wheat is often advised to lower risk of CHD. Studies considering grains as a whole are bound to give inconsistent results since different grains seem to have opposite effects in the case of CHD. So as much as possible future studies should treat grains separately and consider things like type of wheat products and genetic variability.

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Read the complete article here or here.

Tuesday, November 12, 2013

Testosterone and the Heart Part Two - Dach

Testosterone and the Heart Part Two by Jeffrey Dach MD



In Part One, we discussed a 2010 study from Boston University in which testosterone was given to immobilized, elderly, obese male smokers.  The study was halted early because of poor outcome with increased heart attacks and “cardiac events”  in the testosterone treated group.

Second Study Shows  Poor Outcome in Testosterone Group

A second study from the University of Texas was just published in JAMA .(2)  This study was done on Veterans undergoing coronary angiography with documented coronary artery disease.  Some of these Veterans had low testosterone levels (below 300) .  These veterans were given testosterone treatment and followed.  At the end of three years of follow up, the untreated men had a  20%  incidence of stroke,  heart attack or death, while the testosterone treated group had a higher 26% incidence.  This is 20% untreated, vs. 26% treated.  Clearly, the testosterone did not miraculously reverse the atherosclerosis disease in this group of veterans.(2-6)

Benefits of Testosterone Clearly Documented in Medical Literature

As discussed in part one, decades of research studies have shown that low testosterone in men is a risk factor for early mortality from cardiovascular disease, and testosterone treatment reduces mortality, especially in the diabetic males. (7-10)

Testosterone Treatment Does Not Reverse Heart Disease

However, it is clear from these two studies that testosterone by itself is insufficient as a therapy to reverse coronary artery plaque in men who have diets and lifestyles which promote heart disease, and who already have significant underlying coronary artery disease.

Track Your Plaque BlogLeft Image logo courtesy of Track Your Plaque Blog.

Track Your Plaque Program

For our office patients who are interested in reversing coronary artery plaque, we use the William Davis MD Track Your Plaque Program. This is an excellent program which is well thought out.  See my article on this: Reversing Heart Disease.


I wonder what the outcome of these two studies would have been if the testosterone treated group had been started on the Track Your Plaque Program which monitors lipo-protein profile and the Calcium Score, and uses diet and lifestyle modification and supplements to reduce Calcium Score and increase LDL particle size.

There are many unanswered questions.  I also  wonder what the Vitamin D levels were, and what the thyroid levels were on these men,   How much trans fats were they consuming?  How much were they smoking and how much alcohol did they consume?  How much overweight were they?

Conclusion

One conclusion seems clear and that is testosterone by itself does not replace the Track Your Plaque Program of Diet, Lifestyle modification and Supplements to reverse heart disease.  As these two studies show, clinical outcomes for Testosterone Treatment may actually be worse for subgroups of men with severe coronary artery disease, especially when no changes are made to the diet and lifestyles that promote heart disease.

Jeffrey Dach MD
7450 Griffin Road, Suite 180/190
Davie, Florida 33314
954-792-4663
www.jeffreydach.com
www.drdach.com
www.naturalmedicine101.com
www.truemedmd.com

Articles With Related Content:

Low Testosterone Diagnosis and Treatment
HCG in Males with Low Testosterone
Testosterone Benefits, PSA and Prostate Part One
Testosterone and PSA Part Two
Clomid for Men with Low Testosterone Part One
Low Testosterone From Pain Pills
Low Testosterone Associated with Increased Mortality
Testosterone Reduces Mortality
Testosterone Blockade Increases Mortality
Testosterone Found Beneficial For Diabetes

Links and References:
(1)http://www.ncbi.nlm.nih.gov/pubmed/20592293
N Engl J Med. 2010 Jul 8;363(2):109-22. Epub 2010 Jun 30.
Adverse events associated with testosterone administration.
Basaria S, Coviello AD, Travison TG, Storer TW, Farwell WR, Jette AM, Eder R, Tennstedt S, Ulloor J, Zhang A, Choong K, Lakshman KM, Mazer NA, Miciek R, Krasnoff J, Elmi A, Knapp PE, Brooks B, Appleman E, Aggarwal S, Bhasin G, Hede-Brierley L, Bhatia A, Collins L, LeBrasseur N, Fiore LD, Bhasin S. Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA.

2) http://jama.jamanetwork.com/article.aspx?articleID=1764051  Association of Testosterone Therapy With Mortality, Myocardial Infarction, and Stroke in Men With Low Testosterone Levels  by Rebecca Vigen, MD, MSCS1; Colin I. O’Donnell, MS2,3; Anna E. Barón, PhD2,3; Gary K. Grunwald, PhD2,3; Thomas M. Maddox, MD, MSc2,3,4; Steven M. Bradley, MD, MPH2,3,4; Al Barqawi, MD3; Glenn Woning, MD3; Margaret E. Wierman, MD2,3; Mary E. Plomondon, PhD2,3,4; John S. Rumsfeld, MD, PhD2,3,4; P. Michael Ho, MD, PhD2,3,4  The University of Texas at Southwestern Medical Center, Dallas 2VA Eastern Colorado Health Care
JAMA. 2013;310(17):1829-1836.

3) http://health.clevelandclinic.org/2013/11/concerns-raised-about-testosterone-therapy/  Concerns Raised about Testosterone Therapy Study: testosterone replacement linked to heart risks By Steven Nissen, MD | 11/8/13 2:26 p.m.
4) Testosterone treatments linked with heart riskshttp://www.thetowntalk.com/viewart/20131112/LIFESTYLE/311130006/Testosterone-treatments-linked-heart-risks
5) http://online.wsj.com/news/articles/SB10001424052702303661404579180294201174958  Testosterone Therapy Tied to Heart Risks
Veterans With History of Heart Disease Had Higher Risk of Death, Heart Attack and Stroke, According

6) http://www.latimes.com/science/sciencenow/la-sci-heart-disease-testosterone-replacement-20131105,0,3592717.story  Testosterone medication may boost risk of heart attack, stroke, death
7) http://www.ncbi.nlm.nih.gov/pubmed/22496507  J Clin Endocrinol Metab. 2012 Jun;97(6):2050-8. doi: 10.1210/jc.2011-2591. Epub 2012 Apr 11.  Testosterone treatment and mortality in men with low testosterone levels. Shores MM, Smith NL, Forsberg CW, Anawalt BD, Matsumoto AM.
Source  Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, S-116PES, Seattle, Washington 98108, USA.

8) http://www.endocrine-abstracts.org/ea/0025/ea0025p163.htm
Endocrine Abstracts (2011) 25 P163
Low testosterone predicts increased mortality and testosterone replacement therapy improves survival in men with type 2 diabetes
Vakkat Muraleedharan1,2, Hazel Marsh1 & Hugh Jones1,2

9) http://www.ncbi.nlm.nih.gov/pubmed/23999642
Eur J Endocrinol. 2013 Oct 21;169(6):725-33. doi: 10.1530/EJE-13-0321. Print 2013.
Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes.
Muraleedharan V, Marsh H, Kapoor D, Channer KS, Jones TH.
Source  Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital NHSFT, Gawber Road, Barnsley S75 2EP, UK.

Jeffrey Dach MD
7450 Griffin Road, Suite 180/190
Davie, Florida 33314
954-792-4663
www.jeffreydach.com
www.drdach.com
www.naturalmedicine101.com
www.truemedmd.com
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Read the complete article here.

Thursday, October 24, 2013

Saturated fat is not the major issue - Malhotra

Saturated fat is not the major issue

BMJ 2013; 347 doi: http://dx.doi.org/10.1136/bmj.f6340 (Published 22 October 2013)
Cite this as: BMJ 2013;347:f6340

Let’s bust the myth of its role in heart disease

Scientists universally accept that trans fats—found in many fast foods, bakery products, and margarines—increase the risk of cardiovascular disease through inflammatory processes.1 But “saturated fat” is another story. The mantra that saturated fat must be removed to reduce the risk of cardiovascular disease has dominated dietary advice and guidelines for almost four decades.

Yet scientific evidence shows that this advice has, paradoxically, increased our cardiovascular risks. Furthermore, the government’s obsession with levels of total cholesterol, which has led to the overmedication of millions of people with statins, has diverted our attention from the more egregious risk factor of atherogenic dyslipidaemia.

Saturated fat has been demonised ever since Ancel Keys’s landmark “seven countries” study in 1970.2 This concluded that a correlation existed between the incidence of coronary heart disease and total cholesterol concentrations, which then correlated with the proportion of energy provided by saturated fat. But correlation is not causation. Nevertheless, we were advised to cut fat intake to 30% of total energy and saturated fat to 10%.”3 The aspect of dietary saturated fat that is believed to have the greatest influence on cardiovascular risk is elevated concentrations of low density lipoprotein (LDL) cholesterol. Yet the reduction in LDL cholesterol from reducing saturated fat intake seems to be specific to large, buoyant (type A) LDL particles, when in fact it is the small, dense (type B) particles (responsive to carbohydrate intake) that are implicated in cardiovascular disease.4

Indeed, recent prospective cohort studies have not supported any significant association between saturated fat intake and cardiovascular risk.5 Instead, saturated fat has been found to be protective. The source of the saturated fat may be important. Dairy foods are exemplary providers of vitamins A and D. As well as a link between vitamin D deficiency and a significantly increased risk of cardiovascular mortality, calcium and phosphorus found commonly in dairy foods may have antihypertensive effects that may contribute to inverse associations with cardiovascular risk.6 7 8

One study showed that higher concentrations of plasma trans-palmitoleic acid, a fatty acid mainly found in dairy foods, was associated with higher concentrations of high density lipoprotein, lower concentrations of triglycerides and C reactive protein, reduced insulin resistance, and a lower incidence of diabetes in adults.9 Red meat is another major source of saturated fat. Consumption of processed meats, but not red meat, has been associated with coronary heart disease and diabetes mellitus, which may be explained by nitrates and sodium as preservatives.10

The notoriety of fat is based on its higher energy content per gram in comparison with protein and carbohydrate. However, work by the biochemist Richard Feinman and nuclear physicist Eugene Fine on thermodynamics and the metabolic advantage of different diet compositions showed that the body did not metabolise different macronutrients in the same way.11 Kekwick and Pawan carried out one of the earliest obesity experiments, published in the Lancet in 1956.12 They compared groups consuming diets of 90% fat, 90% protein, and 90% carbohydrate and showed that the greatest weight loss was in the fat consuming group. The authors concluded that the “composition of the diet appeared to outweigh in importance the intake of calories.”

The “calorie is not a calorie” theory has been further substantiated by a recent JAMA study showing that a “low fat” diet resulted in the greatest decrease in energy expenditure, an unhealthy lipid pattern, and increased insulin resistance in comparison with a low carbohydrate and low glycaemic index diet.13 In the past 30 years in the United States the proportion of energy from consumed fat has fallen from 40% to 30% (although absolute fat consumption has remained the same), yet obesity has rocketed.

One reason: when you take the fat out, the food tastes worse. The food industry compensated by replacing saturated fat with added sugar. The scientific evidence is mounting that sugar is a possible independent risk factor for the metabolic syndrome (the cluster of hypertension, dysglycaemia, raised triglycerides, low HDL cholesterol, and increased waist circumference).

In previous generations cardiovascular disease existed largely in isolation. Now two thirds of people admitted to hospital with a diagnosis of acute myocardial infarction really have metabolic syndrome—but 75% of these patients have completely normal total cholesterol concentrations.14 Maybe this is because total cholesterol isn’t really the problem?

The Framingham heart study sanctified total cholesterol as a risk factor for coronary artery disease, making statins the second most prescribed drug in the US and driving a multibillion dollar global industry. In the United Kingdom eight million people take statins regularly, up from five million 10 years ago. With 60 million statin prescriptions a year, it is difficult to demonstrate any additional effect of statins on reduced cardiovascular mortality over the effects of the decline in smoking prevalence and primary angioplasty.15

Despite the common belief that high cholesterol is a significant risk factor for coronary artery disease, several independent population studies in healthy adults have shown that low total cholesterol is associated with cardiovascular and non-cardiac mortality, indicating that high total cholesterol is not a risk factor in a healthy population.16 17 18

A recent “real world” study of 150 000 patients who were taking statins showed “unacceptable” side effects—including myalgia, gastrointestinal upset, sleep and memory disturbance, and erectile dysfunction—in 20% of participants, resulting in discontinuation of the drug.19 This is massively at odds with the major statin trials that report significant side effects of myopathy or muscle pain in only one in 10 000.

A meta-analysis of predominantly industry sponsored data reported that in a low risk group of people aged 60-70 years taking statins the number needed to treat (NNT) to prevent one cardiovascular event in one year was 345.20 The strongest evidence base for statins is in secondary prevention, where all patients after a myocardial infarction are prescribed maximum dose treatment irrespective of total cholesterol, because of statins’ anti-inflammatory or pleiotropic (coronary plaque stabilising) effects. In this group the NNT is 83 for mortality over five years. This doesn’t mean that each patient benefits a little but rather that 82 will receive no prognostic benefit.21 The fact that no other cholesterol lowering drug has shown a benefit in terms of mortality supports the hypothesis that the benefits of statins are independent of their effects on cholesterol.

Adopting a Mediterranean diet after a heart attack is almost three times as powerful in reducing mortality as taking a statin. The recently published PREDIMED randomised controlled trial was stopped early after it showed that in high risk people the Mediterranean diet achieved a 30% improvement over a “low fat” diet in terms of cardiovascular events.22

Pharmacotherapy can assuage the symptoms but can’t alter the pathophysiology. Doctors need to embrace prevention as well as treatment. The greatest improvements in morbidity and mortality have been due not to personal responsibility but rather to public health. It is time to bust the myth of the role of saturated fat in heart disease and wind back the harms of dietary advice that has contributed to obesity.

Notes

Cite this as: BMJ 2013;347:f6340
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Read the complete article here.

Read also - Top heart doctor: Unprocessed fatty foods may actually be good for you

Watch this excellent video on saturated fat and heart disease. http://www.abc.net.au/catalyst/stories/3876219.htm
Here are some quotes from the video:

Dr Johnny Bowden
"Sugar is far more damaging to the heart than fat ever was, and we're beginning to see this now. So, this focus on cholesterol has been incredibly destructive because we haven't looked at these real promoters of heart disease - inflammation, oxidative damage, sugar in the diet, and number one with a bullet - stress."


Dr Johnny Bowden
"Margarine is the perfect example of the stupidest nutritional swap-out in history. We had this trans fat-laden crappy manufactured product that we were eating because we were so phobic about saturated fat and cholesterol."

Dr Stephen Sinatra
"To switch to polyunsaturated fats with the vegetable oils, that's horrific advice. The polyunsaturated fats, the vegetable oils, these omega-6 oils, are inflammatory because they're very prone to oxidation."


Dr Stephen Sinatra
"It took decades to really entrench this myth. It's probably going to take a few more decades to get us out of this myth. But to vilify saturated fats I think is one of the worst things the medical profession has done."

Dr Ernest Curtis
"I'd love to see the medical establishment saying, 'Whoops, we were wrong'. That's not going to happen. Frankly, that generation is going to have to die off, and perhaps the generation coming up can do better."

Friday, October 19, 2012

LDL is not “bad cholesterol” & it cannot build up in artery walls. Read the truth.

Cholesterol: Friend Or Foe?
Written by Natasha Campbell-McBride, MD
Sunday, 04 May 2008 19:17
The art of medicine consists in amusing the patient while nature cures the disease. --Voltaire
In our modern world, cholesterol has become almost a swear word. Thanks to the promoters of the diet-heart hypothesis, everybody "knows" that cholesterol is "evil" and has to be fought at every turn. If you believe the popular media, you would think that there is simply no level of cholesterol low enough. If you are over a certain age, you are likely to be tested for how much cholesterol you have in your blood. If it is higher than about 200 mg/100ml (5.1 mol/l), you may be prescribed a "cholesterol pill." Millions of people around the world take these pills, thinking that this way they are taking good care of their health. What these people don’t realize is just how far from the truth they are. The truth is that we humans cannot live without cholesterol. Let us see why.

Our bodies are made out of billions of cells. Almost every cell produces cholesterol all the time during all of our lives. Why? Because every cell of every organ has cholesterol as a part of its structure. Cholesterol is an integral and very important part of our cell membranes, the membranes that enclose each of our cells, and also of the membranes surrounding all the organelles inside the cell. What is cholesterol doing there? A number of things.

Structural Integrity

First of all, saturated fats and cholesterol make the membranes of the cells firm—without them the cells would become flabby and fluid. If we humans didn’t have cholesterol and saturated fats in the membranes of our cells, we would look like giant worms or slugs. And we are not talking about a few molecules of cholesterol here and there. In many cells, almost half of the cell membrane is made from cholesterol. Different kinds of cells in the body need different amounts of cholesterol, depending on their function and purpose. If the cell is part of a protective barrier, it will have a lot of cholesterol in it to make it strong, sturdy and resistant to any invasion. If a cell or an organelle inside the cell needs to be soft and fluid, it will have less cholesterol in its structure.

This ability of cholesterol and saturated fats to firm up and reinforce the tissues in the body is used by our blood vessels, particularly those that have to withstand the high pressure and turbulence of the blood flow. These are usually large or medium arteries in places where they divide or bend. The flow of blood pounding through these arteries forces them to incorporate a layer of cholesterol and saturated fat in the membranes, which makes it stronger, tougher and more rigid. These layers of cholesterol and fat are called fatty streaks. They are completely normal and form in all of us, starting from birth and sometimes even before we are born. Various indigenous populations around the world, who never suffer from heart disease, have plenty of fatty streaks in their blood vessels in old and young, including children. Fatty streaks are not indicative of the disease called atherosclerosis.

Lipid Lifesavers

All the cells in our bodies have to communicate with each other. How do they do that? They use proteins embedded into the membrane of the cell. How are these proteins fixed to the membrane? With the help of cholesterol and saturated fats! Cholesterol and stiff saturated fatty acids form so-called lipid rafts, which make little homes for every protein in the membrane and allow it to perform its functions. Without cholesterol and saturated fats, our cells would not be able to communicate with each other or to transport various molecules into and out of the cell. As a result, our bodies would not be able to function the way they do. The human brain is particularly rich in cholesterol: around 25 percent of all body cholesterol is accounted for by the brain. Every cell and every structure in the brain and the rest of our nervous system needs cholesterol, not only to build itself but also to accomplish its many functions. The developing brain and eyes of the fetus and a newborn infant require large amounts of cholesterol. If the fetus doesn’t get enough cholesterol during development, the child may be born with a congenital abnormality called cyclopean eye.1

Human breast milk provides a lot of cholesterol. Not only that, mother’s milk provides a specific enzyme to allow the baby’s digestive tract to absorb almost 100 percent of that cholesterol, because the developing brain and eyes of an infant require large amounts of it. Children deprived of cholesterol in infancy may end up with poor eyesight and brain function. Manufacturers of infant formulas are aware of this fact, but following the anti-cholesterol dogma, they produce formulas with virtually no cholesterol in them.

Vital Brain Matter

One of the most abundant materials in the brain and the rest of our nervous system is a fatty substance called myelin. Myelin coats every nerve cell and every nerve fiber like the insulating cover around electric wires. Apart from insulation, it provides nourishment and protection for every tiny structure in our brain and the rest of the nervous system. People who start losing their myelin develop a condition called multiple sclerosis. Well, 20 percent of myelin is cholesterol. If you start interfering with the body’s ability to produce cholesterol, you put the very structure of the brain and the rest of the nervous system under threat.

The synthesis of myelin in the brain is tightly connected with the synthesis of cholesterol. In my clinical experience, foods with high cholesterol and high animal fat content are an essential medicine for a person with multiple sclerosis. One of the most wonderful abilities we humans are blessed with is the ability to remember things—our human memory. How do we form memories? By our brain cells establishing connections with each other, called synapses. The more healthy synapses a person’s brain can make, the more mentally able and intelligent that person is. Scientists have discovered that synapse formation is almost entirely dependent on cholesterol, which is produced by the brain cells in a form called apolipoprotein E. Without the presence of this factor we cannot form synapses, and hence we would not be able to learn or remember anything. Memory loss is one of the side effects of cholesterol-lowering drugs.

In my clinic, I see growing numbers of people with memory loss who have been taking cholesterol- lowering pills. Dr Duane Graveline, MD, former NASA scientist and astronaut, suffered such memory loss while taking his cholesterol pill. He managed to save his memory by stopping the pill and eating lots of cholesterol-rich foods. Since then he has described his experience in his book, Lipitor: Thief of Memory, Statin Drugs and the Misguided War on Cholesterol. Dietary cholesterol in fresh eggs and other cholesterol-rich foods has been shown in scientific trials to improve memory in the elderly. In my clinical experience, any person with memory loss or learning problems needs to have plenty of these foods every single day in order to recover.

Necessary Product Of The Body

These foods give the body a hand in supplying cholesterol so it does not have to work as hard to produce its own. What a lot of people don’t realize is that most cholesterol in the body does not come from food! The body produces cholesterol as it is needed. Scientific studies have conclusively demonstrated that cholesterol from food has no effect whatsoever on the level of our blood cholesterol. Why? Because cholesterol is such an essential part of our human physiology that the body has very efficient mechanisms to keep blood cholesterol at a certain level.

When we eat more cholesterol, the body produces less; when we eat less cholesterol, the body produces more. As a raw material for making cholesterol the body can use carbohydrates, proteins and fats, which means that your pasta and bread can be used for making cholesterol in the body. It has been estimated that, in an average person, about 85 percent of blood cholesterol is produced by the body, while only 15 percent comes from food. So, even if you religiously follow a completely cholesterol-free diet, you will still have a lot of cholesterol in your body. However, cholesterol-lowering drugs are a completely different matter! They interfere with the body’s ability to produce cholesterol, and hence they do reduce the amount of cholesterol available for the body to use.

Dangers Of Low Cholesterol

If we do not take cholesterol-lowering drugs, most of us don’t have to worry about cholesterol. However, there are people whose bodies, for whatever reason, are unable to produce enough cholesterol. These people are prone to emotional instability and behavioral problems. Low blood cholesterol has been routinely recorded in criminals who have committed murder and other violent crimes, people with aggressive and violent personalities, people prone to suicide and people with aggressive social behavior and low self-control.

I would like to repeat what the late Oxford professor David Horrobin warned us about: "Reducing cholesterol in the population on a large scale could lead to a general shift to more violent patterns of behavior. Most of this increased violence would not result in death but in more aggression at work and in the family, more child abuse, more wife-beating and generally more unhappiness."

People whose bodies are unable to produce enough cholesterol do need to have plenty of foods rich in cholesterol in order to provide their organs with this essential-to-life substance.
What else does our body need all that cholesterol for?

Endocrine System

After the brain, the organs hungriest for cholesterol are our endocrine glands: adrenals and sex glands. They produce steroid hormones. Steroid hormones in the body are made from cholesterol: testosterone, progesterone, pregnenolone, androsterone, estrone, estradiol, corticosterone, aldosterone and others. These hormones accomplish a myriad of functions in the body, from regulation of our metabolism, energy production, mineral assimilation, brain, muscle and bone formation to behavior, emotions and reproduction. In our stressful modern lives we consume a lot of these hormones, leading to a condition called "adrenal exhaustion." This condition is diagnosed very often by naturopaths and other health practitioners. There are many herbal preparations on the market for adrenal exhaustion. However, the most important therapeutic measure is to provide your adrenal glands with plenty of dietary cholesterol.

Without cholesterol we would not be able to have children because every sex hormone in our bodies is made from cholesterol. A fair percentage of our infertility epidemic can be laid at the doorstep of the diet-heart hypothesis. The more eager we became to fight animal fats and cholesterol, the more problems with normal sexual development, fertility and reproduction we started to face. About a third of western men and women are infertile, and increasing numbers of our youngsters are growing up with abnormalities in their sex hormones. These abnormalities lead to many physical problems.

Recent research has "discovered" that eating full-cream dairy products cures infertility in women.2 Researchers found that women who drink whole milk and eat high-fat dairy products are more fertile than those who stick to low-fat products. Study leader Dr Jorge Chavarro, of the Harvard School of Public Health, emphasized: "Women wanting to conceive should examine their diet. They should consider changing low-fat dairy foods for high-fat dairy foods, for instance by swapping skimmed milk for whole milk and eating cream, not low-fat yoghurt."

The Liver And Vitamin Regulation

One of the busiest organs in terms of cholesterol production in our bodies is the liver, which regulates the level of our blood cholesterol. The liver also puts a lot of cholesterol into bile production. Yes, bile is made out of cholesterol. Without bile we would not be able to digest and absorb fats and fat-soluble vitamins. Bile emulsifies fats; in other words, it mixes them with water, so that digestive enzymes can get to them. After it completes its mission, most of the bile gets reabsorbed in the digestive system and brought back to the liver for recycling. In fact, 95 percent of our bile is recycled because the building blocks of bile, one of which is cholesterol, are too precious for the body to waste. Nature doesn’t do anything without good reason. This example of the careful recycling of cholesterol alone should have given us a good idea about its importance for the body!
Bile is essential for absorbing fat-soluble vitamins: vitamin A, vitamin D, vitamin K and vitamin E. We cannot live without these vitamins. Apart from ensuring that fat-soluble vitamins get digested and absorbed properly, cholesterol is the major building block of one of these vitamins: vitamin D. Vitamin D is made from the cholesterol in our skin when it is exposed to sunlight. In those times of the year when there isn’t much sunlight, we can get this vitamin from cholesterol-rich foods: cod liver oil, fish, shellfish, butter, lard and egg yolks. Our recent misguided fears of the sun and avoidance of cholesterol-rich foods have created an epidemic of vitamin D deficiency in the Western world.

Unfortunately, apart from sunlight and cholesterol-rich foods there is no other appropriate way to get vitamin D. Of course, there are supplements, but most of them contain vitamin D2, which is made by irradiating mushrooms and other plants. This vitamin is not the same as the natural vitamin D. It does not work as effectively and it is easy to get a toxic level of it. In fact, almost all cases of vitamin D toxicity ever recorded were cases where this synthetic vitamin D2 had been used. Toxicity is almost impossible with natural vitamin D obtained from sunlight or cholesterol-rich foods because the body knows how to deal with an excess of natural substances. What the body does not know how to deal with is an excess of synthetic vitamin D2.

Vitamin D has been designed to work as a team with another fat-soluble vitamin: vitamin A. That is why foods rich in one tend to be rich in the other. So, by taking cod liver oil, for example, we can obtain both vitamins at the same time. As we grow older, our ability to produce vitamin D in the skin under sunlight is considerably diminished. Taking foods rich in vitamin D is therefore particularly important for older people. For the rest of us, sensible sunbathing is a wonderful, healthy and enjoyable way of getting a good supply of vitamin D.

Skin cancer, blamed on sunshine, is not caused by the sun. It is caused by trans fats from vegetable oils and margarine and other toxins stored in the skin. In addition, some of the sunscreens that people use contain chemicals that have been proven to cause skin cancer3.

Immune System Health

Cholesterol is essential for our immune system to function properly. Animal experiments and human studies have demonstrated that immune cells rely on cholesterol in fighting infections and repairing themselves after the fight. In addition, LDL-cholesterol (low-density lipoprotein cholesterol), the so-called "bad" cholesterol, directly binds and inactivates dangerous bacterial toxins, preventing them from doing any damage in the body. One of the most lethal toxins is produced by a widely spread bacterium, Staphylococcus aureus, which is the cause of MRSA (Methicillin- resistant Staphylococcus aureus), a common hospital infection. This toxin can literally dissolve red blood cells. However, it does not work in the presence of LDL-cholesterol. People who fall prey to this toxin have low blood cholesterol. It has been recorded that people with high levels of cholesterol are protected from infections; they are four times less likely to contract AIDS, they rarely get common colds and they recover from infections more quickly than people with "normal" or low blood cholesterol.

People with low blood cholesterol are prone to various infections, suffer from them longer and are more likely to die from an infection. A diet rich in cholesterol has been demonstrated to improve these people’s ability to recover from infections. So, any person suffering from an acute or chronic infection needs to eat high-cholesterol foods to recover. Cod liver oil, the richest source of cholesterol (after caviar), has long been prized as the best remedy for the immune system. Those familiar with old medical literature will tell you that until the discovery of antibiotics, a common cure for tuberculosis was a daily mixture of raw egg yolks and fresh cream.

Varying Blood Cholesterol Levels

The question is, why do some people have more cholesterol in their blood than others, and why can the same person have different levels of cholesterol at different times of the day? Why is our level of cholesterol different in different seasons of the year? In winter it goes up and in the summer it goes down. Why is it that blood cholesterol goes through the roof in people after any surgery? Why does blood cholesterol go up when we have an infection? Why does it go up after dental treatment? Why does it go up when we are under stress? And why does it become normal when we are relaxed and feel well? The answer to all these questions is this: cholesterol is a healing agent in the body. When the body has some healing jobs to do, it produces cholesterol and sends it to the site of the damage. Depending on the time of day, the weather, the season and our exposure to various environmental agents, the damage to various tissues in the body varies. As a result, the production of cholesterol in the body also varies.

Since cholesterol is usually discussed in the context of disease and atherosclerosis, let us look at the blood vessels. Their inside walls are covered by a layer of cells called the endothelium. Any damaging agent we are exposed to will finish up in our bloodstream, whether it is a toxic chemical, an infectious organism, a free radical or anything else. Once such an agent is in the blood, what is it going to attack first? The endothelium, of course. The endothelium immediately sends a message to the liver. Whenever our liver receives a signal that a wound has been inflicted upon the endothelium somewhere in our vascular system, it gets into gear and sends cholesterol to the site of the damage in a shuttle, called LDL-cholesterol. Because this cholesterol travels from the liver to the wound in the form of LDL, our "science," in its wisdom calls LDL "bad" cholesterol. When the wound heals and the cholesterol is removed, it travels back to the liver in the form of HDLcholesterol (high-density lipoprotein cholesterol). Because this cholesterol travels away from the artery back to the liver, our misguided "science" calls it "good" cholesterol. This is like calling an ambulance travelling from the hospital to the patient a "bad ambulance," and the one travelling from the patient back to the hospital a "good ambulance."

But the situation has gotten even more ridiculous. The latest thing that our science has "discovered" is that not all LDL-cholesterol is so bad. Most of it is actually good. So, now we are told to call that part of LDL the "good bad cholesterol" and the rest of it the "bad bad cholesterol."

Marvelous Healing Agent

Why does the liver send cholesterol to the site of the injury? Because the body cannot clear the infection, remove toxic elements or heal the wound without cholesterol and fats. Any healing involves the birth, growth and functioning of thousands of cells: immune cells, endothelial cells and many others. As these cells, to a considerable degree, are made out of cholesterol and fats, they cannot form and grow without a good supply of these substances. When the cells are damaged, they require cholesterol and fats to repair themselves. It is a scientific fact that any scar tissue in the body contains good amounts of cholesterol.4

Another scientific fact is that cholesterol acts as an antioxidant in the body, dealing with free radical damage.5 Any wound in the body contains plenty of free radicals because the immune cells use these highly reactive molecules for destroying microbes and toxins. Excess free radicals have to be neutralized, and cholesterol is one of the natural substances that accomplishes this function.

When we have surgery, our tissues are cut and many small arteries, veins and capillaries get damaged. The liver receives a very strong signal from this damage, so it floods the body with LDL-cholesterol to clean and heal every little wound in our blood vessels. That is why blood cholesterol goes high after any surgical procedure. After dental treatment, in addition to the damage to the tissues, a lot of bacteria from the tooth and the gums finish up in the blood, attacking the inside walls of our blood vessels. Once again, the liver gets a strong signal from that damage and produces lots of healing cholesterol to deal with it, so the blood cholesterol goes up.

The same thing happens when we have an infection: LDL-cholesterol goes up to deal with the bacterial or viral attack.

Apart from the endothelium, our immune cells need cholesterol to function and to heal themselves after the fight with the infection.

Our stress hormones are made out of cholesterol in the body. Stressful situations increase our blood cholesterol levels because cholesterol is being sent to the adrenal glands for stress hormone production. Apart from that, when we are under stress, a storm of free radicals and other damaging biochemical reactions occur in the blood. So the liver works hard to produce and send out as much cholesterol as possible to deal with the free radical attack. In situations like this, your blood cholesterol will test high. In short, when we have a high blood cholesterol level, it means that the body is dealing with some kind of damage. The last thing we should do is interfere with this process! When the damage has been dealt with, the blood cholesterol will naturally go down. If we have an ongoing disease in the body that constantly inflicts damage, then the blood cholesterol will be permanently high. So, when a doctor finds high cholesterol in a patient, what this doctor should do is to look for the reason. The doctor should ask, "What is damaging the body so that the liver has to produce all that cholesterol to deal with the damage?" Unfortunately, instead of this sensible procedure, our doctors are trained to attack the cholesterol.

Many natural herbs, antioxidants and vitamins have an ability to reduce our blood cholesterol. How do they do that? By helping the body remove the damaging agents, be they free radicals, bacteria, viruses or toxins. As a result, the liver does not have to produce so much cholesterol to deal with the damage. At the same time, vitamins, minerals, antioxidants, herbs and other natural remedies help to heal the wound. When the wound heals there is no need for high levels of cholesterol anymore, so the body removes it in the form of HDL-cholesterol or so-called "good" cholesterol. That is why herbs, vitamins, antioxidants and other natural remedies increase the level of HDL-cholesterol in the blood.

In conclusion, cholesterol is one of the most important substances in the body. We cannot live without it, let alone function well. The pernicious diet-heart hypothesis has vilified this essential substance. Unfortunately, this hypothesis has served many commercial and political interests far too well, so they ensure its long survival. However, the life of the diet-heart hypothesis is coming to an end as we become aware that cholesterol has been mistakenly blamed for the crime just because it was found at the scene.


Dietary Sources Of Cholesterol

  1. Caviar is the richest source; it provides 588 mg of cholesterol per 100 grams. Obviously, this is not a common food for the majority of us, so let us have a look at the next item on the list.
  2. Cod liver oil follows closely with 570 mg of cholesterol per 100 grams. There is no doubt that the cholesterol element of cod liver oil plays an important role in all the well-known health benefits of this time-honored health food.
  3. Fresh egg yolk takes third place, with 424 mg of cholesterol per 100 gram. I would like to repeat: fresh egg yolk, not chemically mutilated egg powders (they contain chemically mutilated cholesterol)!
  4. Butter provides a good 218 mg of cholesterol per 100 gram. We are talking about natural butter, not butter substitutes.
  5. Cold-water fish and shellfish, such as salmon, sardines, mackerel and shrimps, provide good amounts of cholesterol, ranging from 173 mg to 81 mg per 100 gram. The proponents of low-cholesterol diets tell you to replace meats with fish. Obviously, they are not aware of the fact that fish is almost twice as rich in cholesterol as meat.
  6. Lard provides 94 mg of cholesterol per 100 gram. Other animal fats follow.

Vitamin D Deficiency

What does it mean for our bodies to be deficient in vitamin D? A long list of suffering:
  • Diabetes, as vitamin D is essential for blood sugar control
  • Heart disease
  • Mental illness
  • Auto-immune illness, such as rheumatoid arthritis, lupus, inflammatory bowel disease and multiple sclerosis
  • Obesity
  • Osteoarthritis
  • Rickets and osteomalacia
  • Muscle weakness and poor neuro-muscular coordination
  • High blood pressure
  • Cancer
  • Chronic pain
  • Poor immunity and susceptibility to infections
  • Hyperparathyroidism, which manifests itself as osteoporosis, kidney stones, depression, aches and pains, chronic fatigue, muscle weakness and digestive abnormalities

References
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  2. Chavarro JI and others. A prospective study of dairy foods intake and anovulatory infertility. Human Reproduction, Issue 28, Feb 2007.
  3. According to one theory, trans fats interfere in the metabolism of omega-3 fats, making them ineffective in producing their derivative eicosanoids, which leads to many types of cancers, including skin cancer. Trans fats also interfere with enzyme systems that help protect the body against cancer. References for the relationship of trans fats to skin cancer include:
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This article appeared in Wise Traditions in Food, Farming and the Healing Arts, the quarterly magazine of the Weston A. Price Foundation, Fall 2007.