Thursday, March 7, 2013

Niacin significantly reduces oxidative stress

2013 Mar;345(3):195-9. doi: 10.1097/MAJ.0b013e3182548c28.

Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol.


Internal Medicine E Department (SH, AH, TH) and Lipid Research Laboratory (SH, EM, TH), Technion Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel; Clinical Biochemistry Laboratory (MK), Technion Faculty of Medicine, Rambam Medical Center, Haifa, Israel; and Medical Department (RT, RC), Merck, Sharp and Dohme, Hod Hasharon, Israel.


ABSTRACT:: Oxidative stress has been implicated in the pathogenesis of cardiovascular disorders, including atherosclerosis. In pharmacological doses, niacin (vitamin B3) was proven to reduce total cholesterol, triglyceride, very-low-density lipoprotein, and low-density lipoprotein levels, and to increase high-density lipoprotein (HDL) levels. The aim of this study was to evaluate the effect of niacin treatment in patients with low levels of HDL cholesterol
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