Vascular Calcification Is Increased With Statin Use

Progression of Vascular Calcification Is Increased With Statin Use in the Veterans Affairs Diabetes Trial (VADT)

1. Aramesh Saremi, MD¹⇓,
2. Gideon Bahn, PHD²,
3. Peter D. Reaven, MD¹ and
4. for the VADT Investigators

+ Author Affiliations

1. ¹Phoenix VA Health Care System, Phoenix, Arizona
2. ²Cooperative Studies Program Coordinating Center, Hines, Illinois

1. Corresponding author: Aramesh Saremi, Aramesh.Saremi@va.gov.

Abstract

OBJECTIVE To determine the effect of statin use on progression of vascular calcification in type 2 diabetes (T2DM).

                   

RESEARCH DESIGN AND METHODS Progression of coronary artery calcification (CAC) and abdominal aortic artery calcification (AAC) was assessed according to the frequency of statin use in 197 participants with T2DM.

                   

RESULTS After adjustment for baseline CAC and other confounders, progression of CAC was significantly higher in more frequent statin users than in less frequent users (mean ± SE, 8.2 ± 0.5 mm³ vs. 4.2 ± 1.1 mm³; P < 0.01). AAC progression was in general not significantly increased with more frequent statin use; in a subgroup of participants initially not receiving statins, however, progression of both CAC and AAC was significantly increased in frequent statin users.

                   

CONCLUSION More frequent statin use is associated with accelerated coronary artery calcification in T2DM patients with advanced atherosclerosis.

© 2012 by the American Diabetes Association.

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